Modulation of Allergenicity of Major House Dust Mite Allergens Der f 1 and Der p 1 by Interaction with an Endogenous Ligand

of April 5 , 2017 . This information is current as Interaction with an Endogenous Ligand Dust Mite Allergens Der f 1 and Der p

Major House Dust Mite Allergens Der p 1 And Der f 1 Degrade And Inactivate Lung Surfactant Proteins –A and –D*

‡ MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK. OX1 3QU ‡‡ Institute of Infection, Immunity & Inflammation, University of Nottingham, Queen's Medical Centre, Nottingham, UK. NG7 2RD ¶ To whom correspondence may be addressed: MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK. OX1 3Q...

Distribution of dust-mite allergens (Lep d 2, Der p 1, Der f 1, Der 2) in pig-farming environments and sensitization of the respective farmers.

BACKGROUND The aim of the present study was to determine the distribution of mite allergens in pig-farming environments in comparison to urban homes and the relationship between exposure to mite allergens and sensitization to the respective allergens in 100 pig farmers with work-related respiratory symptoms. METHODS The concentration of storage mite (Lep d 2) and house-dust-mite (Der p 1, Der...

Extraction of house dust mite allergen, Der p 1, from dust.

A recent article in this journal found that the type of extraction buffer did not affect measured levels of the major group one allergen (Der p 1) from the house dust mite, Dermatophagoides pteronyssinus, in household dust samples (1). This differed from a previous study where about twice the levels of Der p 1 were found in borate-buffered saline extracts, compared to ammonium bicarbonate buffe...

House dust mite Der p 1 downregulates defenses of the lung by inactivating elastase inhibitors.

House dust mites (HDM) are the most common source of aeroallergens and in genetic susceptible individuals can cause symptoms ranging from atopic dermatitis to bronchial asthma. Der p 1, a major target of the human immune responses to HDM, through its enzymatic properties can modulate the adaptive immune system by the cleavage of CD23 and CD25. The consequences of this would be to promote allerg...